Icilin | TRPM8 activator

CAS:
36945-98-9
Catalog Number:
10-4380
Activity:
TRPM8 activator
Alternate Names:
AG 3-5
Chemical Name:
3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one
Molecular Weight:
311.29
Molecular Formula:
C16H13N3O4
Solubility:
Soluble in DMSO (up to 25 mg/ml),
Physical Properties:
Yellow solid
Purity:
>98% by TLC
NMR (conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$65.00
50 mg$245.00

Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50 = 0.2 μM)2 and ANKTM1(TRPA1)3. Activator effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5

References/Citations:

1) McKemy et al. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation; Nature, 416 52
2) Andersson et al. (2004) TRPM8 activation by menthol, icilin and cold is differentially modulated by intracellular pH; J .Neurosci., 24 5364
3) Story et al. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures; Cell, 112 819
4) Chuang et al. (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel; Neuron, 43 859
5) Kim et al. (2011) Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner; Biochem. Biophys. Res .Commun., 406 30

CAS:
36945-98-9
Catalog Number:
10-4380
Activity:
TRPM8 activator
Alternate Names:
AG 3-5
Chemical Name:
3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one
Molecular Weight:
311.29
Molecular Formula:
C16H13N3O4
Solubility:
Soluble in DMSO (up to 25 mg/ml),
Physical Properties:
Yellow solid
Purity:
>98% by TLC
NMR (conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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