Size : | Price | Quantity | |
---|---|---|---|
10 mg | $65.00 | ||
50 mg | $245.00 |
Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50 = 0.2 μM)2 and ANKTM1(TRPA1)3. Activator effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
References/Citations:
1) McKemy et al. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation; Nature, 416 52
2) Andersson et al. (2004) TRPM8 activation by menthol, icilin and cold is differentially modulated by intracellular pH; J .Neurosci., 24 5364
3) Story et al. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures; Cell, 112 819
4) Chuang et al. (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel; Neuron, 43 859
5) Kim et al. (2011) Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner; Biochem. Biophys. Res .Commun., 406 30
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Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50 = 0.2 μM)2 and ANKTM1(TRPA1)3. Activator effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
References/Citations:
1) McKemy et al. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation; Nature, 416 52
2) Andersson et al. (2004) TRPM8 activation by menthol, icilin and cold is differentially modulated by intracellular pH; J .Neurosci., 24 5364
3) Story et al. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures; Cell, 112 819
4) Chuang et al. (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel; Neuron, 43 859
5) Kim et al. (2011) Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner; Biochem. Biophys. Res .Commun., 406 30
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