Icilin | TRPM8 activator
NMR (conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $245.00 |
Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50 = 0.2 μM)2 and ANKTM1(TRPA1)3. Activator effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
References/Citations:
1) McKemy et al. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation; Nature, 416 52
2) Andersson et al. (2004) TRPM8 activation by menthol, icilin and cold is differentially modulated by intracellular pH; J .Neurosci., 24 5364
3) Story et al. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures; Cell, 112 819
4) Chuang et al. (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel; Neuron, 43 859
5) Kim et al. (2011) Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner; Biochem. Biophys. Res .Commun., 406 30
NMR (conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50 = 0.2 μM)2 and ANKTM1(TRPA1)3. Activator effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
References/Citations:
1) McKemy et al. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation; Nature, 416 52
2) Andersson et al. (2004) TRPM8 activation by menthol, icilin and cold is differentially modulated by intracellular pH; J .Neurosci., 24 5364
3) Story et al. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures; Cell, 112 819
4) Chuang et al. (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel; Neuron, 43 859
5) Kim et al. (2011) Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner; Biochem. Biophys. Res .Commun., 406 30
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