ICRF-193 | Topoisomerase II poison
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $125.00 | ||
| 5 mg | $485.00 |
ICRF-193 (21416-88-6) is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1β secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5
References/Citations:
- Huang et al. (2001), Topoisomerase II Poisoning by ICRF-193; J. Biol. Chem. 276 44488
- Hajji et al. (2003), DNA strand breaks induced by the anti-topoisomerase bis-dioxopiperazine ICRF-193; Mutat. Res. 530 35
- Jirkovskai et al. (2021), Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIß Interactions; J. Med. Chem. 64 3997
- Brindle et al. (2024), The Bisdioxopiperazine ICRF-193 Attenuates LPS-induced IL-1ß Secretion by Macrophages; Inflammation 47 84
- Morotomi-Yano et al. (2018), Dynamic behavior of DNA topoisomerase IIß in response to DNA double-strand breaks; Sci. Rep. 8 10344
C12H18N4O4
>98% (TLC)
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ICRF-193 (21416-88-6) is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1β secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5
References/Citations:
- Huang et al. (2001), Topoisomerase II Poisoning by ICRF-193; J. Biol. Chem. 276 44488
- Hajji et al. (2003), DNA strand breaks induced by the anti-topoisomerase bis-dioxopiperazine ICRF-193; Mutat. Res. 530 35
- Jirkovskai et al. (2021), Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIß Interactions; J. Med. Chem. 64 3997
- Brindle et al. (2024), The Bisdioxopiperazine ICRF-193 Attenuates LPS-induced IL-1ß Secretion by Macrophages; Inflammation 47 84
- Morotomi-Yano et al. (2018), Dynamic behavior of DNA topoisomerase IIß in response to DNA double-strand breaks; Sci. Rep. 8 10344
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