iCRT5 | Beta-catenin inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $57.00 | ||
| 25 mg | $228.00 |
iCRT5 (18623-44-4) is a selective CRT (β-catenin-responsive transcription) inhibitor.1 IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1 Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2 Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3 Modulators of Wnt signaling show great promise in animal models of several cancers.4 Cell permeable.
References/Citations:
1) Gonsalves et al. (2011), An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway; Proc. Natl. Acad. Sci. USA, 108 5954
2) Bilir et al. (2013), Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells; J. Transl. Med., 11 280
3) Kafer et al. (2016), Inhibitors of β-catenin affect the immune-phenotype and functions of dendritic cells in an inhibitor-specific manner; Immunopharmacol., 32 118
4) Anastas et al. (2013), WNT signaling pathways as therapeutic targets in cancer; Nat. Rev. Cancer, 13 11
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
iCRT5 (18623-44-4) is a selective CRT (β-catenin-responsive transcription) inhibitor.1 IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1 Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2 Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3 Modulators of Wnt signaling show great promise in animal models of several cancers.4 Cell permeable.
References/Citations:
1) Gonsalves et al. (2011), An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway; Proc. Natl. Acad. Sci. USA, 108 5954
2) Bilir et al. (2013), Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells; J. Transl. Med., 11 280
3) Kafer et al. (2016), Inhibitors of β-catenin affect the immune-phenotype and functions of dendritic cells in an inhibitor-specific manner; Immunopharmacol., 32 118
4) Anastas et al. (2013), WNT signaling pathways as therapeutic targets in cancer; Nat. Rev. Cancer, 13 11
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1-855-FOCUS21
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