Size: | Price | Quantity | |
---|---|---|---|
5 mg | $50.00 | ||
25 mg | $180.00 |
iGP-1 (27031-00-1) is a potent and cell permeable inhibitor of mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), IC50=6.3 μM, that is selective over the cytosolic enzyme1. It does not block pyruvate uptake into cells or mitochondria and has no direct effect on glycolysis in synaptosomes. This novel inhibitor is a unique tool which may be used to investigate the role of glycerol-3-phosphate metabolism in isolated and intact systems.1
References/Citations:
1) Orr et al. (2014), Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase; PLoS One, 9 e89938
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iGP-1 (27031-00-1) is a potent and cell permeable inhibitor of mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), IC50=6.3 μM, that is selective over the cytosolic enzyme1. It does not block pyruvate uptake into cells or mitochondria and has no direct effect on glycolysis in synaptosomes. This novel inhibitor is a unique tool which may be used to investigate the role of glycerol-3-phosphate metabolism in isolated and intact systems.1
References/Citations:
1) Orr et al. (2014), Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase; PLoS One, 9 e89938
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