iJMJD6 | Arginine demethylase JMJD6 inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $75.00 | ||
| 25mg | $285.00 |
iJMJD6 (899548-78-8) is an inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins.1 Exhibited antiproliferative effects in HeLa (EC50 = 1.49 µM), SMCC7721 (EC50 = 9.37 µM), and MCF7 (EC50 = 9.53 µM) cells.2 Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.2
References/Citations:
- Ran et al. (2019), In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment; ACS Med. Chem. Lett. 10 1609
- Xiao et al. (2022), A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo; Proc. Natl. Acad. Sci. USA 119 e2200753119
C16H11N3O2
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
iJMJD6 (899548-78-8) is an inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins.1 Exhibited antiproliferative effects in HeLa (EC50 = 1.49 µM), SMCC7721 (EC50 = 9.37 µM), and MCF7 (EC50 = 9.53 µM) cells.2 Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.2
References/Citations:
- Ran et al. (2019), In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment; ACS Med. Chem. Lett. 10 1609
- Xiao et al. (2022), A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo; Proc. Natl. Acad. Sci. USA 119 e2200753119
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