IM-12 | GSK-3ß inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $52.00 | ||
| 25 mg | $176.00 |
IM-12 (129669-05-1) is a potent and selective inhibitor of glycogen synthase kinase 3ß (GSK-3ß) IC50=53 nM which induces neuronal differentiation.1 Activates the Wnt-ß-catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models.2 Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone.3 Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation.4
- Schmöle et al. (2010), Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells; Bioorg. Med. Chem., 18 6785
- Wang et al. (2019), IM-12 activates the Wnt-ß-catenin signaling pathway and attenuates rtPA-induced hemorrhagic transformation in rats after acute ischemic stroke; Cell Biol., 97 702
- Chen et al. (2020), Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline and abiraterone as potential covid-19 treatments with a robust two-tier screening system; Front. Pharmacol., 10 1528
- Menzel-Severing et al. (2018), Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/progenitor cells; Sci. Rep., 8 10268
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
IM-12 (129669-05-1) is a potent and selective inhibitor of glycogen synthase kinase 3ß (GSK-3ß) IC50=53 nM which induces neuronal differentiation.1 Activates the Wnt-ß-catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models.2 Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone.3 Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation.4
- Schmöle et al. (2010), Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells; Bioorg. Med. Chem., 18 6785
- Wang et al. (2019), IM-12 activates the Wnt-ß-catenin signaling pathway and attenuates rtPA-induced hemorrhagic transformation in rats after acute ischemic stroke; Cell Biol., 97 702
- Chen et al. (2020), Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline and abiraterone as potential covid-19 treatments with a robust two-tier screening system; Front. Pharmacol., 10 1528
- Menzel-Severing et al. (2018), Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/progenitor cells; Sci. Rep., 8 10268
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