IMR-1 | Notch transcriptional activation inhibitor

CAS:
310456-65-6
Catalog Number:
10-3601
Activity:
Notch transcriptional activation inhibitor
Chemical Name:
2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester
Molecular Weight:
353.41
Molecular Formula:
C15H15NO5S2
Solubility:
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$60.00
25 mg$240.00

Inhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1 IC50=26 µM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 µM (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1

References/Citations:

1) Austudilo et al. (2016), The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis; Cancer Res., 76 3593

CAS:
310456-65-6
Catalog Number:
10-3601
Activity:
Notch transcriptional activation inhibitor
Chemical Name:
2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester
Molecular Weight:
353.41
Molecular Formula:
C15H15NO5S2
Solubility:
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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