Size: | Price | Quantity | |
---|---|---|---|
5 mg | $60.00 | ||
25 mg | $240.00 |
Inhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1 IC50=26 µM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 µM (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
References/Citations:
1) Austudilo et al. (2016), The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis; Cancer Res., 76 3593
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Inhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1 IC50=26 µM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 µM (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
References/Citations:
1) Austudilo et al. (2016), The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis; Cancer Res., 76 3593
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