IMR-1 | Notch transcriptional activation inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $240.00 |
Inhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1 IC50=26 µM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 µM (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
References/Citations:
1) Austudilo et al. (2016), The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis; Cancer Res., 76 3593
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Inhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1 IC50=26 µM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 µM (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
References/Citations:
1) Austudilo et al. (2016), The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis; Cancer Res., 76 3593
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