IMT1 | Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $300.00 |
IMT1 (2304621-31-4) is a specific inhibitor of mitochondrial DNA (mtDNA) transcription. It targets an allosteric binding site on human mitochondrial RNA polymerase leading to impairment of biogenesis of the oxidative phosphorylation (OXPHOS) system.1 IMT1 treatment of 89 cancer cell lines lead to a strong decrease in cell viability in one third of them without affecting normal cells. It inhibited proliferation and migration in squamous cell2 and endometrial carcinoma cells3.
References/Citations:
- Bonekamp, et al. (2020), Small-molecule inhibitors of human mitochondrial DNA transcription; Nature, 588 712
- Wang, et al. (2022), The mitochondrial RNA polymerase POLRMT promotes skin squamous cell carcinoma growth; Cell Death Discov., 8 347
- Li, et al. (2023), A first-in-class POLRMT specific inhibitor IMT1 suppresses endometrial carcinoma cell growth; Cell Death Dis., 14 152
C21H21NO4
>98% by TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
IMT1 (2304621-31-4) is a specific inhibitor of mitochondrial DNA (mtDNA) transcription. It targets an allosteric binding site on human mitochondrial RNA polymerase leading to impairment of biogenesis of the oxidative phosphorylation (OXPHOS) system.1 IMT1 treatment of 89 cancer cell lines lead to a strong decrease in cell viability in one third of them without affecting normal cells. It inhibited proliferation and migration in squamous cell2 and endometrial carcinoma cells3.
References/Citations:
- Bonekamp, et al. (2020), Small-molecule inhibitors of human mitochondrial DNA transcription; Nature, 588 712
- Wang, et al. (2022), The mitochondrial RNA polymerase POLRMT promotes skin squamous cell carcinoma growth; Cell Death Discov., 8 347
- Li, et al. (2023), A first-in-class POLRMT specific inhibitor IMT1 suppresses endometrial carcinoma cell growth; Cell Death Dis., 14 152
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Plymouth Meeting, PA USA
1-855-FOCUS21
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