IMT1B | Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $125.00 | ||
| 25 mg | $450.00 |
IMT1B (2304621-06-3) is a specific inhibitor of mitochondrial DNA (mtDNA) transcription. It targets an allosteric binding site on human mitochondrial RNA polymerase leading to impairment of biogenesis of the oxidative phosphorylation (OXPHOS) system.1 IMT1B displayed efficacy in mice containing human A2780 or DLD-1 cancer cell xenografts. IC50 = 138 nM A2780 cancer cells.2
References/Citations:
- Bonekamp, et al. (2020), Small-molecule inhibitors of human mitochondrial DNA transcription; Nature, 588 712
- Li, et al. (2023), Discovery of a Novel, Potent, Orally Active, and Safe Inhibitor Targeting Human Mitochondrial RNA Polymerase; J. Med. Chem., 66 5118
C24H21ClFNO6
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
IMT1B (2304621-06-3) is a specific inhibitor of mitochondrial DNA (mtDNA) transcription. It targets an allosteric binding site on human mitochondrial RNA polymerase leading to impairment of biogenesis of the oxidative phosphorylation (OXPHOS) system.1 IMT1B displayed efficacy in mice containing human A2780 or DLD-1 cancer cell xenografts. IC50 = 138 nM A2780 cancer cells.2
References/Citations:
- Bonekamp, et al. (2020), Small-molecule inhibitors of human mitochondrial DNA transcription; Nature, 588 712
- Li, et al. (2023), Discovery of a Novel, Potent, Orally Active, and Safe Inhibitor Targeting Human Mitochondrial RNA Polymerase; J. Med. Chem., 66 5118
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