Indolactam V | PKC activator/Stem cell inducer
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 ug | $66.00 | ||
| 500 ug | $262.00 |
Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2 Directs differentiation of human and mouse ESCs to pancreatic cells.3 May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4 Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5
References/Citations:
1) Fujiki et al. (1984), Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin; Gan., 75 866
2) Heikkila and Ackerman (1989), (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells; Biochem. Biophys. Res. Commun, 162 1207
3) Chen et al. (2009), A small molecule that directs differentiation of human ESCs into the pancreatic lineage; Nat. Chem. Biol., 5 258
4) Thalava et al. (2011), Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secretin progeny; Gene Ther., 18 283
5) Raveh (2014), Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts; Mol. Pharmacol., 86 406
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2 Directs differentiation of human and mouse ESCs to pancreatic cells.3 May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4 Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5
References/Citations:
1) Fujiki et al. (1984), Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin; Gan., 75 866
2) Heikkila and Ackerman (1989), (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells; Biochem. Biophys. Res. Commun, 162 1207
3) Chen et al. (2009), A small molecule that directs differentiation of human ESCs into the pancreatic lineage; Nat. Chem. Biol., 5 258
4) Thalava et al. (2011), Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secretin progeny; Gene Ther., 18 283
5) Raveh (2014), Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts; Mol. Pharmacol., 86 406
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