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Product Details

Indolactam V | PKC activator; Stem cell inducer

Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2 Directs differentiation of human and mouse ESCs to pancreatic cells.3   May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4 Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5


1) Fujiki et al. (1984), Structure-activity atudies on synthetic analogues (indolactams) of the tumor promoter teleocidin; Gann, 75 866
2) Heikkila and Ackerman (1989), (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells; Biochem. Biophys. Res. Commun, 162 1207
3) Chen et al. (2009), A small molecule that directs differentiation of human ESCs into the pancreatic lineage; Nat. Chem. Biol., 5 258
4) Thalava et al. (2011), Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secretin progeny; Gene Ther., 18 283
5) Raveh (2014), Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts; Mol. Pharmacol., 86 406

Focus Biomolecules supplier, chemical structure of Indolactam V | PKC activator | Stem cell inducer | CAS 90365-57-4

Catalog#  10-2145-0100

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Catalog Number:
PKC activator; Stem cell inducer
Chemical Name:
Alternate Names:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
Waxy lyophilized solid
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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