my account
Login
  Loading... Please wait...

Product Details

Indolactam V | PKC activator; Stem cell inducer

Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2 Directs differentiation of human and mouse ESCs to pancreatic cells.3   May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4 Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5

References/Citations

1) Fujiki et al. (1984), Structure-activity atudies on synthetic analogues (indolactams) of the tumor promoter teleocidin; Gann, 75 866
2) Heikkila and Ackerman (1989), (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells; Biochem. Biophys. Res. Commun, 162 1207
3) Chen et al. (2009), A small molecule that directs differentiation of human ESCs into the pancreatic lineage; Nat. Chem. Biol., 5 258
4) Thalava et al. (2011), Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secretin progeny; Gene Ther., 18 283
5) Raveh (2014), Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts; Mol. Pharmacol., 86 406

swipe
Image 1

Catalog#  10-2145-0100

$64.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
90365-57-4
Catalog Number:
10-2145
Activity:
PKC activator; Stem cell inducer
Chemical Name:
(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
Alternate Names:
ILV
Molecular Weight:
000.00
Molecular Formula:
C17H23N3O2
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
Waxy lyophilized solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Indolactam V | PKC activator; Stem cell inducer to your wish list.