Indoximod | IDO modulator / tryptophan mimetic
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 50 mg | $20.00 | ||
| 250 mg | $55.00 |
Indoximod (110117-83-4) is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.4
References/Citations:
1) Hou et al. (2007), Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses; Cancer Res., 67 792
2) Soliman et al. (2010), Indoleamine 2,3-dioxygenase: is it an immune suppressor?; Cancer J., 16 354
3) Friberg et al. (2002), Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T-cell mediated rejection; Int. J. Cancer, 101 151
4) Metz et al. (2012), IDO inhibits a tryptophan sufficiency signal that stimulates mTOR; Oncoimmunol., 1 1460
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Indoximod (110117-83-4) is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.4
References/Citations:
1) Hou et al. (2007), Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses; Cancer Res., 67 792
2) Soliman et al. (2010), Indoleamine 2,3-dioxygenase: is it an immune suppressor?; Cancer J., 16 354
3) Friberg et al. (2002), Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T-cell mediated rejection; Int. J. Cancer, 101 151
4) Metz et al. (2012), IDO inhibits a tryptophan sufficiency signal that stimulates mTOR; Oncoimmunol., 1 1460
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