Ingenol-3-angelate | PKC activator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $110.00 | ||
| 5 mg | $430.00 |
Ingenol-3-angelate (75567-37-2) is a selective activator of protein kinase C which displays antileukemic activity mediated via PKCδ.1 In contrast, it provides a strong survival signal to resting and activated human T cells via activation of PKC and downstream activation of NFκB.2 Treatment of subcutaneous tumors results in anti-cancer CD8 T cells, also displays adjuvant activity and synergizes with cancer immunotherapies.3 Induces senescence-like growth arrest in solid tumor cells.4 Inhibits HIV-1 infection at an early pathway of viral entry.5
References/Citations
1) Hampson et al. (2005), PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC; Blood, 106 1362
2) Lee et al. (2010), Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta; J. Biol. Chem., 285 23889
3) Le et al. (2009), Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies; Vaccine, 27 3053
4) Mason et al. (2010), The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells; Invest. New Drugs, 28 575
5) Warrilow et al. (2006), HIV type 1 inhibition by protein kinase C modulatory compounds; AIDS Res. Hum. Retroviruses, 22 854
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ingenol-3-angelate (75567-37-2) is a selective activator of protein kinase C which displays antileukemic activity mediated via PKCδ.1 In contrast, it provides a strong survival signal to resting and activated human T cells via activation of PKC and downstream activation of NFκB.2 Treatment of subcutaneous tumors results in anti-cancer CD8 T cells, also displays adjuvant activity and synergizes with cancer immunotherapies.3 Induces senescence-like growth arrest in solid tumor cells.4 Inhibits HIV-1 infection at an early pathway of viral entry.5
References/Citations
1) Hampson et al. (2005), PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC; Blood, 106 1362
2) Lee et al. (2010), Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta; J. Biol. Chem., 285 23889
3) Le et al. (2009), Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies; Vaccine, 27 3053
4) Mason et al. (2010), The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells; Invest. New Drugs, 28 575
5) Warrilow et al. (2006), HIV type 1 inhibition by protein kinase C modulatory compounds; AIDS Res. Hum. Retroviruses, 22 854
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