INK-128 | TORC1/2 inhibitor

CAS:
1224844-38-5
Catalog Number:
10-3362
Activity:
TORC1/2 inhibitor
Chemical Name:
3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Alternate Names:
MLN-0128
Molecular Weight:
309.33
Molecular Formula:
C15H15N7O
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC/HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$50.00
25 mg$180.00

INK-128 (1224844-38-5) is a potent and selective, ATP-competitive inhibitor of mTOR kinase, Ki = 1.4 nM.1 Inhibits growth and proliferation of various breast cancer cell lines and human endothelial cells.2

References/Citations:

1) Hsieh et al. (2012), The translational landscape of mTOR signaling steers cancer initiation and metastasis; Nature, 485 55
2) Gokmen-Polar et al. (2012) Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models; Breast Cancer Res. Treat., 136 673

CAS:
1224844-38-5
Catalog Number:
10-3362
Activity:
TORC1/2 inhibitor
Chemical Name:
3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Alternate Names:
MLN-0128
Molecular Weight:
309.33
Molecular Formula:
C15H15N7O
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC/HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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