IOX 1 | JMJD demethylase inhibitor

CAS:
5852-78-8
Catalog Number:
10-1426
Activity:
JMJD demethylase inhibitor
Alternate Names:
5-Carboxy-8HQ
Chemical Name:
8-Hydroxy-5-quinolinecarboxylic acid
Molecular Weight:
189.17
Molecular Formula:
C10H7NO3
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$72.00
25 mg$288.00

IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1 A broad spectrum 2-oxoglutarate oxygenase inhibitor, IOX 1 may be used to study hypoxic signaling.1 Cell permeable

References/Citations:

1) King et al. (2010), Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors; PLoS One, 5 e15535

CAS:
5852-78-8
Catalog Number:
10-1426
Activity:
JMJD demethylase inhibitor
Alternate Names:
5-Carboxy-8HQ
Chemical Name:
8-Hydroxy-5-quinolinecarboxylic acid
Molecular Weight:
189.17
Molecular Formula:
C10H7NO3
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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