IPA-3 | Selective inhibitor of PAK1

CAS:
42521-82-4
Catalog Number:
10-4765
Activity:
Selective inhibitor of PAK1
Chemical Name:
1,1′-Dithiodi-2-naphthol
Molecular Weight:
350.45
Molecular Formula:
C20H14O2S2
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$65.00
50 mg$240.00

IPA-3 (42521-82-4) is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50 = 2.5 µM)1 via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc422. IPA-3 has been shown to induce cell death in human leukemic cell lines3, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition4 and inhibit the growth of liver cancer cells5.

References/Citations:

1) Deacon et al. (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase; Chem.Biol., 14 322
2) Viaud and Peterson (2009) An allosteric kinase inhibitor binds the p21-activated kinase (PAK) autoregulatory domain covalently; Mol. Cancer Ther., 8 2559
3) Kuzelova et al. (2014) Group 1 PAK Inhibitor IPA-3 Induces Cell Death and Affects Cell Adhesivity to Fibronectin in Human Hematopoietic Cells; PLoS One, 9 e92560
4) Al-Azayzih et al. (2015) P21 Activated Kinase-1 Mediates Transforming Growth factor b1-Induced Prostate Cancer Cell Epithelial to Mesenchymal transition; Biochim. Biophys. Acta, 1853 1229
5) Wong et al. (2013) IPA-3 Inhibits the Growth of Liver Cancer Cells By Suppressing PAK1 and NF-kB Activation; PLoS One, 8 e68843

CAS:
42521-82-4
Catalog Number:
10-4765
Activity:
Selective inhibitor of PAK1
Chemical Name:
1,1′-Dithiodi-2-naphthol
Molecular Weight:
350.45
Molecular Formula:
C20H14O2S2
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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