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Product Details

IPA-3 | Selective inhibitor of PAK1

IPA-3 (42521-82-4) is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50 = 2.5 µM)1 via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc422. IPA-3 has been shown to induce cell death in human leukemic cell lines3, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition4 and inhibit the growth of liver cancer cells5.

References/Citations

1) Deacon et al. (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase; Chem.Biol., 14 322
2) Viaud and Peterson (2009) An allosteric kinase inhibitor binds the p21-activated kinase (PAK) autoregulatory domain covalently; Mol. Cancer Ther., 8 2559
3) Kuzelova et al. (2014) Group 1 PAK Inhibitor IPA-3 Induces Cell Death and Affects Cell Adhesivity to Fibronectin in Human Hematopoietic Cells; PLoS One, 9 e92560
4) Al-Azayzih et al. (2015) P21 Activated Kinase-1 Mediates Transforming Growth factor b1-Induced Prostate Cancer Cell Epithelial to Mesenchymal transition; Biochim. Biophys. Acta, 1853 1229
5) Wong et al. (2013) IPA-3 Inhibits the Growth of Liver Cancer Cells By Suppressing PAK1 and NF-kB Activation; PLoS One, 8 e68843

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Focus Biomolecules cell signaling reagent supplier, chemical structure IPA-3 | Selective inhibitor of PAK1 | CAS 42521-82-4

Catalog#  10-4765-0010

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
42521-82-4
Catalog Number:
10-4765
Activity:
Selective inhibitor of PAK1
Chemical Name:
1,1'-Dithiodi-2-naphthol
Molecular Weight:
350.45
Molecular Formula:
C20H14O2S2
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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