Ipatasertib | pan-Akt inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $65.00 | ||
| 25 mg | $240.00 |
Ipatasertib (1001264-89-6) is a selective (against a panel of 230 kinases) and potent pan-Akt inhibitor (IC50s: Akt1 = 5 nM, Akt2 = 18 nM, Akt3 = 8 nM).1 It displayed efficacy in xenograft models of prostate, breast, ovarian, colorectal, non-small cell lung, glioblastoma, and melanoma cancers.2 In clinical trials.
References:
- Blake et al. (2012), Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors; Med. Chem. 55 8110
- Lin et al. (2013), Targeting Activated Akt with GDC-0068, a Novel Selective Aky Inhibitor That is Efficacious in Multiple Tumor Models; Clin. Cancer Res. 19 1760
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ipatasertib (1001264-89-6) is a selective (against a panel of 230 kinases) and potent pan-Akt inhibitor (IC50s: Akt1 = 5 nM, Akt2 = 18 nM, Akt3 = 8 nM).1 It displayed efficacy in xenograft models of prostate, breast, ovarian, colorectal, non-small cell lung, glioblastoma, and melanoma cancers.2 In clinical trials.
References:
- Blake et al. (2012), Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors; Med. Chem. 55 8110
- Lin et al. (2013), Targeting Activated Akt with GDC-0068, a Novel Selective Aky Inhibitor That is Efficacious in Multiple Tumor Models; Clin. Cancer Res. 19 1760
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