iPHF8 | Inhibitor of lysine demethylase PHF8

CAS:
 N/A
Catalog Number:
 10-4049
iPHF8 chemical structure Focus Biomolecules

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5 mg$75.00
25 mg$240.00

iPHF8 is a specific inhibitor (IC50 = 2.01 µM; EC50 = 2 µM in HeLa cells) of the human non-heme 2-oxoglutarate JmjC domain oxygenase/lysine demethylase PHF8. PHF8 also demethylates the transcription factor YY1 acting as a co-repressor for many electron transport chain genes driving mROS production and cancer development. It inhibited mROS production, cell proliferation, and colony formation in HCT116 and H1299 cells.  iPHF8 significantly decreased tumor size in HCT116 derived tumors and colon cancer patient-derived xenografts.

References/Citations:

  1. Wu et al. (2024), Targeting the PHF8/YY1 axis suppresses cancer cell growth through modulation of ROS; Proc. Natl. Acad. Sci. 121 e2219352120
CAS:
N/A
Catalog Number:
10-4049
Activity:
Inhibitor of lysine demethylase PHF8
Chemical Names:
N-(2,3,4,9-Tetrahydro-1H-carbazol-1-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide
Molecular Weight:
320.40
Molecular Formula:

C19H20N4O

Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% by HPLC
NMR: Conforms

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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