IQ-1S | JNK3 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $40.00 | ||
| 25 mg | $140.00 |
IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppressive activity. Inhibits LPS-induced proinflammatory cytokine and nitric oxide release in vitro.1 Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo.2
References/Citations:
1) Schepetkin et al. (2012), Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors; Mol. Pharmacol., 81 832
2) Schepetkin et al. (2015), Anti-Inflammatory effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1A, a Selective c-Jun N-Terminal Kinase Inhibitor; J. Pharmacol. Exp. Ther., 353 505
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppressive activity. Inhibits LPS-induced proinflammatory cytokine and nitric oxide release in vitro.1 Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo.2
References/Citations:
1) Schepetkin et al. (2012), Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors; Mol. Pharmacol., 81 832
2) Schepetkin et al. (2015), Anti-Inflammatory effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1A, a Selective c-Jun N-Terminal Kinase Inhibitor; J. Pharmacol. Exp. Ther., 353 505
Related products
-
SR1001 | RORα gamma inverse agonist
From $80.00CAS:1335106-03-0Catalog Number:10-1290Activity:RORα inverse agonistChemical Name:N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamideMolecular Weight:477.39Molecular Formula:C15H13F6N6O4S2Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).Physical Properties:Pale beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
MK-571 | Cys LT1 antagonist
From $60.00CAS:115104-28-4Catalog Number:10-1039Activity:Cys LT1 antagonistAlternate Names:L-660711Chemical Name:5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acidMolecular Weight:515.09Molecular Formula:C26H27ClN2O3S2Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:95% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT -
FK-506 | FKBP inhibitor
From $50.00CAS:104987-11-3Catalog Number:10-1103Activity:FKBP inhibitorAlternate Names:TacrolimusMolecular Weight:804.04Molecular Formula:C44H69NO12Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
