Ivabradine HCl | Heart failure / unstable angina drug

CAS:
1448849-67-6
Catalog Number:
10-2694
Activity:
Heart failure / unstable angina drug
Chemical Name:
3-[3-[[(7S)-3,4-Dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
Molecular Weight:
505.05
Molecular Formula:
C27H36N2O5 • HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$60.00
50 mg$220.00

Ivabradine (148849-67-6) is a clinically useful heart failure and chronic unstable angina medication.1 It lowers heart rate via inhibition of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) expressed in the sinoatrial node (IC50’s: HCN1 = 2.05 µM, HCN2 = 2.29 µM, HCN3 = 2.51 µM, HCN4 = 2.15 µM).2

References/Citations
1) Ide et al. (2019), Ivabradine for the Treatment of Cardiovascular Diseases; Circ. J. 83 252
2) Stieber et al. (2006), Bradycardic and Proarrhythmic Properties of Sinus Node Inhibitors; Mol. Pharmacol. 69 1328

CAS:
1448849-67-6
Catalog Number:
10-2694
Activity:
Heart failure / unstable angina drug
Chemical Name:
3-[3-[[(7S)-3,4-Dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
Molecular Weight:
505.05
Molecular Formula:
C27H36N2O5 • HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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