Ivermectin | Nuclear transport inhibitor

CAS:
70288-86-7
Catalog Number:
10-2628
Activity:
Nuclear transport inhibitor
Chemical Name:
22,23-Dihydroavermectin B1
Alternate Name:
22,23-Dihydro C076B1; MK-933
Molecular Weight:
875.09
Molecular Formula:
C48H74O14 (B1a form)
Solubility:
Soluble in DMSO (up to 70 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Contains up to 10% B1b form
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
500 mg$30.00
2 grams$85.00

Ivermectin (70288-86-7) is a  specific inhibitor of importin α/β-mediated nuclear import with no effect on a range of other nuclear import pathways.1   Displays potent antiviral activity against HIV-1, dengue1, corona2 and other viruses. Clinically useful broad-spectrum antiparasitic agent.3

References/Citations
1) Wagstaff et al. (2012), Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus; Biochem. J., 443 851
2) Caly et al. (2020), The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro; Antiviral Res., 178 104787
3) Ottesen and Campbell (1994), Ivermectin in human medicine; J. Antimicrob. Chemother., 34 195

CAS:
70288-86-7
Catalog Number:
10-2628
Activity:
Nuclear transport inhibitor
Chemical Name:
22,23-Dihydroavermectin B1
Alternate Name:
22,23-Dihydro C076B1; MK-933
Molecular Weight:
875.09
Molecular Formula:
C48H74O14 (B1a form)
Solubility:
Soluble in DMSO (up to 70 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Contains up to 10% B1b form
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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