JC-1 | Mitochondrial membrane potential probe
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $55.00 | ||
| 5 mg | $200.00 |
JC-1 (CAS 3520-43-2) is a dual emission, potential-sensitive, carbocyanine probe which can be used to measure mitochondrial membrane potential. When excited at 490 nm the monomer exhibits an emission maximum at 527 nm and J-aggregates at 590 nm.1,2 JC-1 changes color reversibly from green to red with increasing mitochondrial membrane potential.3 May be used for isolation of live cells expressing high multidrug resistance transport activity.4 A widely used probe for determination of mitochondrial membrane potential.5
References/Citations:
1) Reers et al. (1991), J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential; Biochemistry, 30 4480
2) Smiley et al. (1991), Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1; Proc. Natl. Acad. Sci. USA, 88 3671
3) Lisa et al. (1995), Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition; J. Physiol., 486 1
4) Wolosin et al. (2017), Application of JC1 for non-toxic isolation of cells with MDR transporter activity by flow cytometry; PLoS One, 12(4) e0174905
5) Wang et al. (2017), A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway; J. Transl. Med., 15 33
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
JC-1 (CAS 3520-43-2) is a dual emission, potential-sensitive, carbocyanine probe which can be used to measure mitochondrial membrane potential. When excited at 490 nm the monomer exhibits an emission maximum at 527 nm and J-aggregates at 590 nm.1,2 JC-1 changes color reversibly from green to red with increasing mitochondrial membrane potential.3 May be used for isolation of live cells expressing high multidrug resistance transport activity.4 A widely used probe for determination of mitochondrial membrane potential.5
References/Citations:
1) Reers et al. (1991), J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential; Biochemistry, 30 4480
2) Smiley et al. (1991), Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1; Proc. Natl. Acad. Sci. USA, 88 3671
3) Lisa et al. (1995), Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition; J. Physiol., 486 1
4) Wolosin et al. (2017), Application of JC1 for non-toxic isolation of cells with MDR transporter activity by flow cytometry; PLoS One, 12(4) e0174905
5) Wang et al. (2017), A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway; J. Transl. Med., 15 33
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