JIB-04 | pan-JUMONJI histone demethylase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $210.00 |
JIB-04 (199596-05-9) is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model.1 Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2 Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3
References/Citations:
1) Wang et al. (2013), A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth; Nature Commun., 4 2035
2) Rechem et al. (2015), Lysine demethylase KDM4A associates with translocation machinery and regulates protein synthesis; Cancer Discov., 5 255
3) Banelli et al. (2017), Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells; Oncotarget, 8 34896
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
JIB-04 (199596-05-9) is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model.1 Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2 Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3
References/Citations:
1) Wang et al. (2013), A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth; Nature Commun., 4 2035
2) Rechem et al. (2015), Lysine demethylase KDM4A associates with translocation machinery and regulates protein synthesis; Cancer Discov., 5 255
3) Banelli et al. (2017), Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells; Oncotarget, 8 34896
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