JZL-184 | MAG lipase inhibitor

CAS:
1101854-58-3
Catalog Number:
10-1021
Activity:
MAG lipase inhibitor
Chemical Name:
4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylate
Molecular Weight:
520.5
Molecular Formula:
C27H24N2O9
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Light yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$62.00
50 mg$248.00
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JZL-184 (1101854-58-3) inhibits MAG lipase (IC50=8 nM) selectively over FAAH. Irreversible. Cell permeable.

References/Citations:

1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects; Nat. Chem. Biol.,5 37
2) Pan et al. (2009), Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylate (JZL 184) enhances retrograde endocannabinoid signaling; J. Pharmacol. Exp. Ther., 331 591
3) Kinsey et al. (2009), Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain; J. Pharmacol. Exp. Ther., 330 902

CAS:
1101854-58-3
Catalog Number:
10-1021
Activity:
MAG lipase inhibitor
Chemical Name:
4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylate
Molecular Weight:
520.5
Molecular Formula:
C27H24N2O9
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Light yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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