my account
Login
  Loading... Please wait...

Product Details

K252A | Kinase inhibitor (pan-specific)

K252a (99533-80-9) is a potent pan-specific protein kinase inhibitor: PKA (Ki = 18 nM), PKC (Ki = 25 nM) PKG (Ki = 20 nM)1. K252a inhibits CaMK (Ki = 1.8 nM)2 and phosphorylase kinase (IC50 = 1.7 nM)3 as well as other kinases4. Induces apoptosis5. Cell permeable.

References/Citations
1) Kase et al. (1987), K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436
2) Hashimoto et al. (1991), Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative KT5926; Biochem. Biophys. Res. Commun., 181 423
3) Berg et al. (1992), K-252a inhibits nerve growth factor-induced trk proto-ooncogene tyrosine phosphorylation and kinase activity; J. Biol. Chem., 267 13
4) Ruegg et al. (1989), Staurosporine, K-252 and UCN-01: potent but non-specific inhibitors of protein kinases; Trends Pharmacol. Sci., 10 218
5) Mohri et al. (1999), K252a induces cell cycle arrest and apoptosis by inhibiting Cdc2 and Cdc25c; Cancer Invest., 17 391

swipe
Focus Biomolecules supplier, chemical structure of K252A | Kinase inhibitor (pan-specific) | CAS 99533-80-9

Catalog#  10-2080

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
99533-80-9
Catalog Number:
10-2080
Activity:
Kinase inhibitor (pan-specific)
Molecular Weight:
467.49
Molecular Formula:
C27H21N3O5
Solubility:
Soluble in DMSO (up to 100 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the K252A | Kinase inhibitor (pan-specific) to your wish list.