KC7F2 | HIF-1α inhibitor

CAS:
927822-86-4
Catalog Number:
10-4714
Activity:
HIF-1alpha inhibitor
Chemical Name:
N,N’-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Molecular Weight:
570.38
Molecular Formula:
C16H16Cl4N2O4S4
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$60.00
50 mg$235.00

KC7F2 (927822-86-4) is an inhibitor of HIF-1α (IC50 = 20 µM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of HIF-1α protein synthesis accompanied by suppression of phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1α protein synthesis.

References/Citations:

1)Narita et al. (2009), Identification of a Novel Small Molecule HIF-1α Translation Inhibitor; Clin. Cancer Res. 15 6128

CAS:
927822-86-4
Catalog Number:
10-4714
Activity:
HIF-1alpha inhibitor
Chemical Name:
N,N’-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Molecular Weight:
570.38
Molecular Formula:
C16H16Cl4N2O4S4
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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