Size: | Price | Quantity | |
---|---|---|---|
10 mg | $60.00 | ||
50 mg | $235.00 |
KC7F2 (927822-86-4) is an inhibitor of HIF-1α (IC50 = 20 µM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of HIF-1α protein synthesis accompanied by suppression of phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1α protein synthesis.
References/Citations:
1)Narita et al. (2009), Identification of a Novel Small Molecule HIF-1α Translation Inhibitor; Clin. Cancer Res. 15 6128
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KC7F2 (927822-86-4) is an inhibitor of HIF-1α (IC50 = 20 µM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of HIF-1α protein synthesis accompanied by suppression of phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1α protein synthesis.
References/Citations:
1)Narita et al. (2009), Identification of a Novel Small Molecule HIF-1α Translation Inhibitor; Clin. Cancer Res. 15 6128
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