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Product Details

KL-001 | Cryptochrome (CRY) activator

KL-001 (309928-48-1) is a novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes.1 Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure.2 KL-001 induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.

References/Citations
1) Hirota et al. (2012), Identification of small molecule activators of cryptochrome; Science, 337 1094
2) Nangle et al. (2013), Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase; Cell Res., 23 1417
3) St. John et al. (2014), Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock; Proc. Natl. Acad. Sci. USA, 11 2040

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KL-001 | 309928-48-1 | Structure | Supplier

Catalog#  10-1411

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
309928-48-1
Catalog Number:
10-1411
Activity:
Cryptochrome (CRY) activator
Chemical Name:
N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
Molecular Weight:
398.46
Molecular Formula:
C21H22N2O4S
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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