KL044 | Cryptochrome stabilizer
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $90.00 | ||
| 25mg | $340.00 |
KL044 (1801856-93-8) is a potent stabilizer of the circadian clock protein cryptochrome (CRY).1 It lengthened the circadian period and repressed Per2 activity in reporter assays with 10-fold more potency than KL001 (Cat# 10-1411). KL044 inhibited melanogenesis and melanosome transport via suppression of the cAMP/PKA/CREB pathway.2
References/Citations:
- Lee et al. (2015), Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock; ChemMedChem. 10 1489
- Gao et al. (2023), Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway; Front. Pharmacol. 14 1081030
C21H14ClN3O
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
KL044 (1801856-93-8) is a potent stabilizer of the circadian clock protein cryptochrome (CRY).1 It lengthened the circadian period and repressed Per2 activity in reporter assays with 10-fold more potency than KL001 (Cat# 10-1411). KL044 inhibited melanogenesis and melanosome transport via suppression of the cAMP/PKA/CREB pathway.2
References/Citations:
- Lee et al. (2015), Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock; ChemMedChem. 10 1489
- Gao et al. (2023), Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway; Front. Pharmacol. 14 1081030
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