KL044 | Cryptochrome stabilizer

CAS:
 1801856-93-8
Catalog Number:
 10-3911
KL044 Supplier | CAS 1801856-93-8 | Focus Biomolecules

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5mg$90.00
25mg$340.00

KL044 (1801856-93-8) is a potent stabilizer of the circadian clock protein cryptochrome (CRY).1 It lengthened the circadian period and repressed Per2 activity in reporter assays with 10-fold more potency than KL001 (Cat# 10-1411).  KL044 inhibited melanogenesis and melanosome transport via suppression of the cAMP/PKA/CREB pathway.2

References/Citations:

  1. Lee et al. (2015), Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock; ChemMedChem. 10 1489
  2. Gao et al. (2023), Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway; Front. Pharmacol. 14 1081030
CAS:
1801856-93-8
Catalog Number:
10-3911
Activity:
Cryptochrome stabilizer
Chemical Names:
2-Carbazol-9-yl-N-(2-chloro-6-cyanophenyl)acetamide
Molecular Weight:
359.81
Molecular Formula:

C21H14ClN3O

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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