L-Buthionine Sulfoximine | GCL inhibitor

CAS:
83730-53-4
Catalog Number:
10-4572
Activity:
GCL inhibitor
Chemical Name:
2(S)-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Molecular Weight:
222.31
Molecular Formula:
C8H18N2O3S
Solubility:
Soluble in Water (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
Shipping Code:
RT

Available Options

Size;PriceQuantity 
100 mg$50.00
250 mg$90.00
This product is also available in the following library:

L-Buthionine sulfoximine (83730-53-4) is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4

References/Citations:

1) Lu et al. (2009), Regulation of glutathione synthesis; Mol. Aspects Med. 30 42
2) Lee et al. (2008), Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine; Mol. Cell Biochem. 318 174
3) Li et al. (2016), The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine; Oncol. Lett. 11 474
4) Glasauer and Chandel (2014), Targeting antioxidants for cancer therapy; Biochem. Pharmacol. 92 90

CAS:
83730-53-4
Catalog Number:
10-4572
Activity:
GCL inhibitor
Chemical Name:
2(S)-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Molecular Weight:
222.31
Molecular Formula:
C8H18N2O3S
Solubility:
Soluble in Water (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!