L-Buthionine Sulfoximine | GCL inhibitor
NMR (Conforms)
Available Options
| Size; | Price | Quantity | |
|---|---|---|---|
| 100 mg | $50.00 | ||
| 250 mg | $90.00 |
L-Buthionine sulfoximine (83730-53-4) is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4
References/Citations:
1) Lu et al. (2009), Regulation of glutathione synthesis; Mol. Aspects Med. 30 42
2) Lee et al. (2008), Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine; Mol. Cell Biochem. 318 174
3) Li et al. (2016), The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine; Oncol. Lett. 11 474
4) Glasauer and Chandel (2014), Targeting antioxidants for cancer therapy; Biochem. Pharmacol. 92 90
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
L-Buthionine sulfoximine (83730-53-4) is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4
References/Citations:
1) Lu et al. (2009), Regulation of glutathione synthesis; Mol. Aspects Med. 30 42
2) Lee et al. (2008), Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine; Mol. Cell Biochem. 318 174
3) Li et al. (2016), The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine; Oncol. Lett. 11 474
4) Glasauer and Chandel (2014), Targeting antioxidants for cancer therapy; Biochem. Pharmacol. 92 90
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1-855-FOCUS21
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