L524-0366 | Fn14 antagonist
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $65.00 | ||
| 25 mg | $260.00 |
L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. L524-0366 completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM.1 L524-0366 is the first compound known to interfere with the TWEAK/Fn14 interaction and may serve as a lead compound for the development of new therapeutics.2
References/Citations:
1) Dhruv et al. (2013), Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis; J. Biol. Chem., 288 32261
2) Cheng et al. (2013), TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic; Front. Immunol., 4 473
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. L524-0366 completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM.1 L524-0366 is the first compound known to interfere with the TWEAK/Fn14 interaction and may serve as a lead compound for the development of new therapeutics.2
References/Citations:
1) Dhruv et al. (2013), Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis; J. Biol. Chem., 288 32261
2) Cheng et al. (2013), TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic; Front. Immunol., 4 473
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