Lamivudine | Reverse transcriptase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 500 mg | $45.00 | ||
| 2 g | $145.00 |
Lamivudine (134678-17-4) is a nucleoside analog reverse transcriptase inhibitor.1 A potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2).2 Displays anti-inflammatory effects, including reduction of inflammasome-related proteins P2X7 and NLRP3, in retinal microvascular endothelial cells treated with high glucose and LPS as well as in streptozotocin diabetic mice.3 Disrupts repeat element life cycle in colorectal cancer.4
References/Citations:
- Arts and Wainberg (1996), Mechanism of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription; Antimicrob. Agents Chemother., 40 527
- Coates et al. (1992), (-)-2’-deoxy-3’-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro; Antimicrob. Agents Chemother., 36 733
- Kong et al. (2022), Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy; Cell Death Dis., 13 336
- Rajukar et al. (2022), Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer; Cancer Discov., 2021 Online ahead of print
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lamivudine (134678-17-4) is a nucleoside analog reverse transcriptase inhibitor.1 A potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2).2 Displays anti-inflammatory effects, including reduction of inflammasome-related proteins P2X7 and NLRP3, in retinal microvascular endothelial cells treated with high glucose and LPS as well as in streptozotocin diabetic mice.3 Disrupts repeat element life cycle in colorectal cancer.4
References/Citations:
- Arts and Wainberg (1996), Mechanism of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription; Antimicrob. Agents Chemother., 40 527
- Coates et al. (1992), (-)-2’-deoxy-3’-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro; Antimicrob. Agents Chemother., 36 733
- Kong et al. (2022), Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy; Cell Death Dis., 13 336
- Rajukar et al. (2022), Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer; Cancer Discov., 2021 Online ahead of print
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