LD2 | PRMT9 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $225.00 |
LD2 (1134334-55-6) is a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. It inhibited the viability of leukemia cells (IC50 = 2-7 µM in various cell lines). LD2 promoted DNA damage leading to cyclic GMP-AMP synthase (cGAS) activation and a type I IFN response. LD2 acted synergistically with anti-PD-1 mAb in an A20 lymphoma syngeneic model, an MA9 AML transplant model as well as a humanized AML mouse model. LD2 treatment led to leukemia stem cell ablation as well as an anticancer immune response.
References/Citations:
- Dong et al. (2024), Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity; Nat. Cancer 5 601
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
LD2 (1134334-55-6) is a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. It inhibited the viability of leukemia cells (IC50 = 2-7 µM in various cell lines). LD2 promoted DNA damage leading to cyclic GMP-AMP synthase (cGAS) activation and a type I IFN response. LD2 acted synergistically with anti-PD-1 mAb in an A20 lymphoma syngeneic model, an MA9 AML transplant model as well as a humanized AML mouse model. LD2 treatment led to leukemia stem cell ablation as well as an anticancer immune response.
References/Citations:
- Dong et al. (2024), Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity; Nat. Cancer 5 601
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