LDN-193189 | Inhibitor of ALK2 and ALK3
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $235.00 |
LDN-193189 HCl (1435934-00-1) is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1 Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells.2-3 LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4
References/Citations:
1) Yu et al. (2008), BMP type 1 receptor inhibition reduces heterotropic ossification; Nature Med.,14 1363
2) Chambers et al. (2012), Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors; Nature Biotechnol. 30 715
3) Kreitzer et al. (2013) A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells, 2 119
4) Lee et al. (2011) BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res. 71 5194
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
LDN-193189 HCl (1435934-00-1) is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1 Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells.2-3 LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4
References/Citations:
1) Yu et al. (2008), BMP type 1 receptor inhibition reduces heterotropic ossification; Nature Med.,14 1363
2) Chambers et al. (2012), Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors; Nature Biotechnol. 30 715
3) Kreitzer et al. (2013) A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells, 2 119
4) Lee et al. (2011) BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res. 71 5194
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