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LDN-193189 | Inhibitor of ALK2 and ALK3

LDN-193189 HCl (1435934-00-1) is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1  Only weak inhibition of ALK4, ALK5, and ALK7 is observed.  Promotes neuronal differentiation of human pluripotent stem cells.2-3  LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4


1) Yu et al. (2008), BMP type 1 receptor inhibition reduces heterotropic ossification; Nature Med.,14 1363
2) Chambers et al. (2012), Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nocicepters; Nature Biotechnol. 30 715
3) Kreitzer et al. (2013) A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells, 2 119
4) Lee et al. (2011) BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res. 71 5194

Focus Biomolecules cell signaling reagent supplier, chemical structure LDN193189 | Selective inhibitor of ALK2/3 | CAS

Catalog#  10-4764-0005

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Catalog Number:
Inhibitor of ALK2 and ALK3
Chemical Name:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline dihydrochloride
Molecular Weight:
Molecular Formula:
C25H22N6 • 2HCl
Soluble in DMSO or in Water (up to 5 mg/ml)
Physical Properties:
Orange-yellow solid
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 montha.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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