Leelamine | Intracellular cholesterol transport inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $200.00 |
Leelamine HCl (16496-99-4) is a lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1 Induces apoptosis in breast cancer2, melanoma3 and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5 Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 µM.6
References/Citations:
1) Kuzu et al. (2014), Leelamine mediated cancer cell death through inhibition of intracellular cholesterol transport; Mol. Cancer Ther., 13 1690
2) Sehrawat et al. (2017), Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation; Am. Mol. Carcinolg., 56 337
3) Chen et al. (2017), Targeting cholesterol transport in circulating melanoma cells to inhibit metastasis; Pigment Cell Melanoma Res., 30 541
4) Singh et al. (2018), Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer; Mol. Cancer Ther., 17 2079
5) Sim et al. (2015), Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer; Arch. Pharm. Res., 38 725
6) Aicher et al. (1999), Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK); Bioorg. Med. Chem. Lett., 9 2223
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Leelamine HCl (16496-99-4) is a lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1 Induces apoptosis in breast cancer2, melanoma3 and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5 Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 µM.6
References/Citations:
1) Kuzu et al. (2014), Leelamine mediated cancer cell death through inhibition of intracellular cholesterol transport; Mol. Cancer Ther., 13 1690
2) Sehrawat et al. (2017), Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation; Am. Mol. Carcinolg., 56 337
3) Chen et al. (2017), Targeting cholesterol transport in circulating melanoma cells to inhibit metastasis; Pigment Cell Melanoma Res., 30 541
4) Singh et al. (2018), Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer; Mol. Cancer Ther., 17 2079
5) Sim et al. (2015), Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer; Arch. Pharm. Res., 38 725
6) Aicher et al. (1999), Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK); Bioorg. Med. Chem. Lett., 9 2223
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