Lenalidomide | Immunomodulator
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $75.00 | ||
| 500 mg | $180.00 |
Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation.2 Selective inhibition of IKZF1 and IKZF3 by lenalidomide in multiple myeloma cells results in cell death.3,4 Cell permeable. Caution: Teratogenic
References/Citations:
1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345
2) Gandhi et al. (2014), Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T-cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN); Br.J. Haematol., 164 811
3) Kronke et al. (2014), Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells; Science, 343 301
4) Lu et al. (2014), The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins; Science., 343 305
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation.2 Selective inhibition of IKZF1 and IKZF3 by lenalidomide in multiple myeloma cells results in cell death.3,4 Cell permeable. Caution: Teratogenic
References/Citations:
1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345
2) Gandhi et al. (2014), Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T-cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN); Br.J. Haematol., 164 811
3) Kronke et al. (2014), Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells; Science, 343 301
4) Lu et al. (2014), The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins; Science., 343 305
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