Lenvatinib | VEGFR inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $220.00 |
Lenvatinib (417716-92-8) is a potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively.1 Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively.1 Suppresses lymph node and lung metastasis in human mammary breast tumor model.2 Suppresses tumor cell migration and invasion.3 Inhibits angiogenesis.4
References/Citations:
1) Matsui et al. (2008), E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition; Int. J. Cancer, 122 664
2) Matsui et al. (2008), Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R)2 and VEGF-R3 kinase; Clin. Cancer Res., 14 5459
3) Glen et al. (2011), E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion; BMC Cancer, 11 309
4) Yamamoto et al. (2014), Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage; Vasc. Cell, 6 18
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lenvatinib (417716-92-8) is a potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively.1 Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively.1 Suppresses lymph node and lung metastasis in human mammary breast tumor model.2 Suppresses tumor cell migration and invasion.3 Inhibits angiogenesis.4
References/Citations:
1) Matsui et al. (2008), E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition; Int. J. Cancer, 122 664
2) Matsui et al. (2008), Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R)2 and VEGF-R3 kinase; Clin. Cancer Res., 14 5459
3) Glen et al. (2011), E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion; BMC Cancer, 11 309
4) Yamamoto et al. (2014), Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage; Vasc. Cell, 6 18
Related products
-
Borrelidin | Angiogenesis inhibitor
From $190.00CAS:7184-60-3Catalog Number:10-1399Activity:Angiogenesis inhibitorAlternate Names:U-78548; C2989; TreponemycinChemical Name:Fermentation from Streptomyces sp.Molecular Weight:489.66Molecular Formula:C28H43NO6Solubility:Soluble in DMSO or in Ethanol.Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Roscovitine | p34/cdc2 inhibitor
From $45.00CAS:186692-46-6Catalog Number:10-1332Activity:p34/cdc2 inhibitorChemical Name:(R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-olMolecular Weight:354.46Molecular Formula:C19H26N6OSolubility:Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
1,4-DPCA | Prolyl hydroxylase inhibitor
From $42.00CAS:331830-20-7Catalog Number:10-2956Activity:Prolyl hydroxylase inhibitorChemical Name:1,4-Dihydrophenonthrolin-4-one-3-carboxylic acidMolecular Weight:240.22Molecular Formula:C13H8N2O3Solubility:Soluble in DMSO (up to 15 mg/ml with warming).Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
