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Product Details

Lenvatinib | VEGFR inhibitor

Lenvatinib (417716-92-8) is a potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively.1  Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively.1 Suppresses lymph node and lung metastasis in human mammary breast tumor model.2 Suppresses tumor cell migration and invasion.3 Inhibits angiogenesis.4

References/Citations

1) Matsui et al. (2008), E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition; Int. J. Cancer, 122 664
2) Matsui et al. (2008), Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R)2 and VEGF-R3 kinase; Clin. Cancer Res., 14 5459
3) Glen et al. (2011), E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion; BMC Cancer, 11 309
4) Yamamoto et al. (2014), Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage; Vasc. Cell, 6 18

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Lenvatinib | VEGFR inhibitor | CAS 417716-92-8

Catalog#  10-3313-0005

$55.00
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CAS:
417716-92-8
Catalog Number:
10-3313
Activity:
VEGFR inhibitor
Chemical Name:
4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide
Alternate Names:
E7080
Molecular Weight:
426.85
Molecular Formula:
C21H19ClN4O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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