Leptomycin B | Nuclear export inhibitor

CAS:
87081-35-4
Catalog Number:
10-2084
Activity:
Nuclear export inhibitor
Molecular Weight:
540.75
Molecular Formula:
C33H48O6
Solubility:
Supplied in solution in ethanol (1 mg/ml). Further dilutions may be made with either ethanol or DMSO.
Physical Properties:
Solution in ethanol (1mg/ml)
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions or dilutions in DMSO are not stable. Solutions should be made fresh and used within one working day.
Shipping Code:
RT

Available Options

size :PriceQuantity 
200 µg$60.00
1 mg$240.00

Leptomycin B (87081-35-4) is an inhibitor of nuclear export of proteins. Acts via covalent binding to and inhibiting CRM1/exportin-1.1 Inhibits the nuclear export of the HIV regulatory protein Rev.2 Leptomycin B stabilizes p53 by blocking its nuclear export.3

References/Citations:

1) Kudo et al. (1998), Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1; Exp. Cell Res., 242 540
2) Wolff et al. (1997), Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA; Chem. Biol., 4 139
3) Freedman and Levine (1998), Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6; Mol. Cell. Biol., 18 7288

CAS:
87081-35-4
Catalog Number:
10-2084
Activity:
Nuclear export inhibitor
Molecular Weight:
540.75
Molecular Formula:
C33H48O6
Solubility:
Supplied in solution in ethanol (1 mg/ml). Further dilutions may be made with either ethanol or DMSO.
Physical Properties:
Solution in ethanol (1mg/ml)
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions or dilutions in DMSO are not stable. Solutions should be made fresh and used within one working day.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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