Leptomycin B rescues mitochondrial function

Journal Club: Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a Lamin A mutant. The study of HGPS and its underlying mechanisms may provide insights into natural physiological aging. Feliciano Monterrubio-Ledezma and coworkers in Mexico City previously reported that the CRM1-mediated nuclear protein export pathway is upregulated in HGPS cells. In a recent paper in Cells, they show that inhibition of CRM1 with Leptomycin B, a specific CRM1 inhibitor, mitigates the senescent phenotype of these cells. Furthermore and remarkably, Leptomycin B treatment induced the recovery of mitochondrial function in HGPS cells.