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Leu-Leu-OMe HBr | Lysosomal damaging agent

Leu-Leu-OMe (16689-14-8) is a lysosomal damaging agent (lysosomotropic). It is condensed into a membranolytic polymer via the transpeptidase action of cathepsin C within lysosomes.1,2 May be used to induce a lysosomal damage model in cells.3,4  LLOMe-induced lysosomal damage elicits ubiquitin puncta formation on lysosomes.1 Induces apoptosis in human mast cells via lysosome destabilization leaving fibroblasts and HEK-293 cells largely resistant.5 Induces lysophagy.4


1) Maejima et al. (2013), Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury; EMBO J., 32 2336
2) Fujita et al. (2013), Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin; J. Cell Biol., 203 115
3) Chauhan et al. (2016), TRIMS and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-directed Autophagy in Endomembrane Damage Homeostasis; Dev. Cell, 39 13
4) Otomo and Yoshimori (2017), Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy-Dependent Recovery; Methods Mol. Biol. 1594 141
5) Melo et al. (2011), Lysosomal membrane permeabilization induces cell death in human mast cells; Scand. J. Immunol., 74 354

Focus Biomolecules cell signaling supplier, chemical structure Leu-Leu-OMe HBr | Lysosomal damaging agent | CAS 16689-14-8

Catalog#  10-3220-0020

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Catalog Number:
Lysosomal damaging agent
Chemical Name:
Leucyl-leucine methyl ester hydrobromide
Alternate Names:
Molecular Weight:
Molecular Formula:
C13H26N2O3 HBr
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 40 mg/ml)
Physical Properties:
White solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
LLOMe-induced lysosomal damage elicits ubiquitin puncta formation on lysosomes
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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