Leupeptin hemisulfate | Trypsin-like cysteine protease inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 25 mg | $80.00 | ||
| 100 mg | $240.00 |
Leupeptin hemisulfate (103476-89-7) is a reversible inhibitor of trypsin-like proteases and cysteine proteases. Inhibits trypsin, plasmin, papain and cathepsin B, H and L.1-3 Blocks various apoptotic pathways in T cells.4 Commonly used in cell lysis buffers to protect proteins from degradation. Typical working concentration is 1µM (0.5 µg/ml).
References/Citations:
1) Aoyagi et al. (1969), Leupeptins, new protease inhibitors from Actinomycetes; J. Antibiot., 22 283
2) Barrett et al. (1981), Cathepsin B, Cathepsin H and Cathepsin L; Methods Enzymol., Pt C, 80 535
3) Knight et al. (1980), Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin; Biochem. J., 189 447
4) Sarin et al. (1995), A protease-dependent TCR-induced death pathway in mature lymphocytes; J. Immunol., 154 5806
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Leupeptin hemisulfate (103476-89-7) is a reversible inhibitor of trypsin-like proteases and cysteine proteases. Inhibits trypsin, plasmin, papain and cathepsin B, H and L.1-3 Blocks various apoptotic pathways in T cells.4 Commonly used in cell lysis buffers to protect proteins from degradation. Typical working concentration is 1µM (0.5 µg/ml).
References/Citations:
1) Aoyagi et al. (1969), Leupeptins, new protease inhibitors from Actinomycetes; J. Antibiot., 22 283
2) Barrett et al. (1981), Cathepsin B, Cathepsin H and Cathepsin L; Methods Enzymol., Pt C, 80 535
3) Knight et al. (1980), Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin; Biochem. J., 189 447
4) Sarin et al. (1995), A protease-dependent TCR-induced death pathway in mature lymphocytes; J. Immunol., 154 5806
Related products
-
Ilomastat (GM-6001) | MMP inhibitor
From $52.00CAS:142880-36-2Catalog Number:10-1339Activity:MMP inhibitorAlternate Names:GM-6001Chemical Name:N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamideMolecular Weight:388.46Molecular Formula:C20H28N4O4Solubility:Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).Physical Properties:White solidPurity:97% by TLCStorage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Epoxomicin | Irreversible 20S proteasome inhibitor
$155.00CAS:134381-21-8Catalog Number:10-1384Activity:Irreversible 20S proteasome inhibitorMolecular Weight:554.73Molecular Formula:C28H50N4O7Solubility:Soluble in DMSO (up to 10 mg/ml).Physical Properties:White solidPurity:97% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.Shipping Code:RT -
SL-01 | p53/mdm2 inhibitor
From $30.00CAS:26049-94-5Catalog Number:10-1326Activity:p53/mdm2 inhibitorAlternate Names:ZPCKChemical Name:N-Benzyloxycarbonyl-L-phenylalaninylchloromethyl ketoneMolecular Weight:331.8Molecular Formula:C18H18ClNO3Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
20% OFF
For Postdoc
Customers!
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.