Size : | Price | Quantity | |
---|---|---|---|
5 mg | $55.00 | ||
25 mg | $200.00 |
LH-846 (639052-78-1) is a potent and selective inhibitor of casein kinase (CK) 1δ. IC50s=0.29, 1.3 and 2.5 μM for δ, ε and α isoforms respectively with no inhibition of CK2. Inhibits CK1δ-mediated phosphorylation and degradation of PER1 protein and lengthens circadian period in U2OS cells.1
References/Citations:
1) Lee et al. (2011), A small molecule modulates circadian rhythms through phosphorylation of the period protein; Agnew Chem. Int. ed. Engl., 50 10608
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LH-846 (639052-78-1) is a potent and selective inhibitor of casein kinase (CK) 1δ. IC50s=0.29, 1.3 and 2.5 μM for δ, ε and α isoforms respectively with no inhibition of CK2. Inhibits CK1δ-mediated phosphorylation and degradation of PER1 protein and lengthens circadian period in U2OS cells.1
References/Citations:
1) Lee et al. (2011), A small molecule modulates circadian rhythms through phosphorylation of the period protein; Agnew Chem. Int. ed. Engl., 50 10608
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