LH-846 | Casein kinase 1 delta inhibitor

CAS:
639052-78-1
Catalog Number:
10-1465
Activity:
Casein kinase 1 delta inhibitor
Chemical Name:
N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Molecular Weight:
316.81
Molecular Formula:
C16H13ClN2OS
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$55.00
25 mg$200.00

LH-846 (639052-78-1) is a potent and selective inhibitor of casein kinase (CK) 1δ. IC50s=0.29, 1.3 and 2.5 μM for δ, ε and α isoforms respectively with no inhibition of CK2. Inhibits CK1δ-mediated phosphorylation and degradation of PER1 protein and lengthens circadian period in U2OS cells.1

References/Citations:

1) Lee et al. (2011), A small molecule modulates circadian rhythms through phosphorylation of the period protein; Agnew Chem. Int. ed. Engl., 50 10608

CAS:
639052-78-1
Catalog Number:
10-1465
Activity:
Casein kinase 1 delta inhibitor
Chemical Name:
N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Molecular Weight:
316.81
Molecular Formula:
C16H13ClN2OS
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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