Lipofermata | Fatty acid transport protein 2 (FATP2) inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $225.00 |
Lipofermata (297180-15-5) is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 µM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
References/Citations:
1) Sandoval et al. (2010), Identification and characterization of small compound inhibitors of human FATP2; Biochem. Pharmacol. 79 990
2) Ahowesso et al. (2015), Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death; Biochem. Pharmacol. 98 167
3) Zhang et al. (2018), Adipocyte-derived lipids mediate melanoma progression via FATP proteins; Cancer Discov. 8 1006
br />
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lipofermata (297180-15-5) is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 µM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
References/Citations:
1) Sandoval et al. (2010), Identification and characterization of small compound inhibitors of human FATP2; Biochem. Pharmacol. 79 990
2) Ahowesso et al. (2015), Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death; Biochem. Pharmacol. 98 167
3) Zhang et al. (2018), Adipocyte-derived lipids mediate melanoma progression via FATP proteins; Cancer Discov. 8 1006
br />
Related products
-
Cantharidin | Phosphatase PP2A inhibitor
From $40.00CAS:56-25-7Catalog Number:10-1013Activity:Phosphatase PP2A inhibitorChemical Name:3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dioneMolecular Weight:196.2Molecular Formula:C10H12O4Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.Shipping Code:RT -
ZM-447439 | Aurora B kinase inhibitor
From $52.00CAS:331771-20-1Catalog Number:10-1037Activity:Aurora B kinase inhibitorChemical Name:N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamideMolecular Weight:513.59Molecular Formula:C29H31N5O4Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
SU-4312 | VEGFR / PDGFR kinase inhibitor
From $70.00CAS:5812-07-7Catalog Number:10-1027Activity:VEGFR / PDGFR kinase inhibitorChemical Name:3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-oneMolecular Weight:264.33Molecular Formula:C 17H 16N 2OSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Orange solidPurity:98% by TLC NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
