Lipoic acid | Endogenous antioxidant and cofactor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 g | $32.00 | ||
| 25 g | $120.00 |
alpha-Lipoic acid (1077-28-7) is an endogenous antioxidant.1,2 Treatment with alpha-lipoic acid increased hepatic nuclear Nrf2 levels, induced Nrf2-mediated gene transcription, and reversed age-related decline in hepatic glutathione levels in a rat model.3 It is an essential cofactor required for catalysis by multiple mitochondrial enzymes including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase and branched-chain ketoacid dehydrogenase among others.4 It has shown efficacy as a treatment in diabetic neuropathy.5
References/Citations:
- Packer et al. (1995), alpha-Lipoic acid as a biological antioxidant; Free Radic. Biol. Med., 19 227
- Shay et al. (2008), α-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant activity; IUBMB Life, 60 362
- Suh et al. (2004), Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid; Proc. Natl. Acad. Sci. USA, 101 3381
- Solmonson and DeBerardinis (2018), Lipoic acid metabolism and mitochondrial redox regulation; J. Biol. Chem., 293 7522
- Papanas and Ziegler (2014), Efficacy of α-lipoic acid in diabetic neuropathy; Expert Opin. Pharmacother., 15 2721
C8H14O2S2
>98% by TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
alpha-Lipoic acid (1077-28-7) is an endogenous antioxidant.1,2 Treatment with alpha-lipoic acid increased hepatic nuclear Nrf2 levels, induced Nrf2-mediated gene transcription, and reversed age-related decline in hepatic glutathione levels in a rat model.3 It is an essential cofactor required for catalysis by multiple mitochondrial enzymes including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase and branched-chain ketoacid dehydrogenase among others.4 It has shown efficacy as a treatment in diabetic neuropathy.5
References/Citations:
- Packer et al. (1995), alpha-Lipoic acid as a biological antioxidant; Free Radic. Biol. Med., 19 227
- Shay et al. (2008), α-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant activity; IUBMB Life, 60 362
- Suh et al. (2004), Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid; Proc. Natl. Acad. Sci. USA, 101 3381
- Solmonson and DeBerardinis (2018), Lipoic acid metabolism and mitochondrial redox regulation; J. Biol. Chem., 293 7522
- Papanas and Ziegler (2014), Efficacy of α-lipoic acid in diabetic neuropathy; Expert Opin. Pharmacother., 15 2721
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