Lisofylline (racemic) | Anti-diabetic and Antiinflammatory agent

CAS:
6493-06-7
Catalog Number:
10-2781
Activity:
Anti-diabetic and Antiinflammatory agent
Alternate Names:
LSF; BL-194
Chemical Name:
1-(5-Hydroxyhexyl)-3,7-dimethylpurine-2,6-dione (racemic)
Molecular Weight:
280.33
Molecular Formula:
C13H20N4O3
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$50.00
50 mg$175.00

Lisofylline (6493-06-7, racemic) displays anti-inflammatory activity. Regulates immune cell function and autoimmune response by inhibition of IL-12 signalling and cytokine production.1 Protects pancreatic beta cells and prevents type I diabetes in non-obese diabetic mice.2 Lisofylline reduces LPS-induced TNF alpha levels in CD-1 mice.3 Cell permeable.

References/Citations:

1) Yang et al. (2005), Lisofylline: a potential lead for the treatment of diabetes; Biochem. Pharmacol., 69 1
2) Yang et al. (2002), The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice; Diabetologia, 45 1307
3) Wyska et al. (2010), Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide; Pharmacology, 85 264

CAS:
6493-06-7
Catalog Number:
10-2781
Activity:
Anti-diabetic and Antiinflammatory agent
Alternate Names:
LSF; BL-194
Chemical Name:
1-(5-Hydroxyhexyl)-3,7-dimethylpurine-2,6-dione (racemic)
Molecular Weight:
280.33
Molecular Formula:
C13H20N4O3
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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