A nonpeptide neurotrophic factor receptor p75 (p75NTR) agonist which promotes survival signaling in neurotrophin-responsive cells.1 Promotes functional recovery in a mouse model of spinal contusion injury.2 Protects neurogenesis after traumatic brain injury.3 Reverses cholinergic neurite dystrophy in Alzheimer’s disease mouse models.4 Stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV-associated neuropathogenesis.5 Orally active and blood-brain barrier permeant.
1) Massa et al. (2006), Small, Nonpeptide p75NTR Ligands Induce Survival Signaling and Inhibit proNGF-Induced Death; J. Neurosci. 26 5288
2) Tep et al., (2013), Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury; J. Neurosci. 33 397
3) Shi et al. (2013), A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury; Stem Cells 31 2561
4) Simmons et al. (2014), A small molecule p75(NTR) ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer’s disease mouse models with mid- to late-stage disease progression; PLoS One 9 e102136
5) Meeker et al. (2016), Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis; Exp. Neurol. 275 Pt.1 182