LNT 1 | FEN1 Inhibitor

CAS:
824983-91-7
Catalog Number:
10-4036
Activity:
FEN1 inhibitor
Chemical Names:
1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione; FEN1-IN-1
Molecular Weight:
332.33
Molecular Formula:
C15H12N2O5S
Solubility:
Soluble in DMSO (15 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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5 mg$70.00
25 mg$230.00
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LNT 1 (824983-91-7) is a potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1).1 It showed similar potency in inhibiting exonuclease 1 (EXO1).2 Induces a DNA damage response and ultimately cell death. FEN1 inhibitors have therapeutic potential for the treatment of cancers that are defective for homologous repair and other DNA repair and DNA damage checkpoint pathways.4

References:

  1. Tumey et al. (2005), The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors; Med. Chem. Lett., 15 277
  2. Exell et al. (2016), Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site; Chem. Biol., 12 815
  3. Ward et al. (2017), Small molecules inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes; PLoS One, 12 e0179278
  4. Guo et al. (2020), FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination; Natl. Acad. Sci USA 117 19415
CAS:
824983-91-7
Catalog Number:
10-4036
Activity:
FEN1 inhibitor
Chemical Names:
1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione; FEN1-IN-1
Molecular Weight:
332.33
Molecular Formula:
C15H12N2O5S
Solubility:
Soluble in DMSO (15 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

LNT 1 (824983-91-7) is a potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1).1 It showed similar potency in inhibiting exonuclease 1 (EXO1).2 Induces a DNA damage response and ultimately cell death. FEN1 inhibitors have therapeutic potential for the treatment of cancers that are defective for homologous repair and other DNA repair and DNA damage checkpoint pathways.4

References:

  1. Tumey et al. (2005), The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors; Med. Chem. Lett., 15 277
  2. Exell et al. (2016), Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site; Chem. Biol., 12 815
  3. Ward et al. (2017), Small molecules inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes; PLoS One, 12 e0179278
  4. Guo et al. (2020), FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination; Natl. Acad. Sci USA 117 19415

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Plymouth Meeting, PA USA
1-855-FOCUS21

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