Lorcainide HCl | Voltage-gated sodium channel blocker
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $150.00 |
Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig cardiac Na+/K+ ATPase and inhibits the enzyme (IC50 = 34 μM).3
References/Citations:
1) Sheldon et al. (1989), Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem., 35 748
2) Lynch et al. (1995), Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther., 273 554
3) Almotrefi et al. (1999), Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol., 77 866
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig cardiac Na+/K+ ATPase and inhibits the enzyme (IC50 = 34 μM).3
References/Citations:
1) Sheldon et al. (1989), Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem., 35 748
2) Lynch et al. (1995), Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther., 273 554
3) Almotrefi et al. (1999), Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol., 77 866
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